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KMID : 0613820140240121345
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Journal of Life Science
2014 Volume.24 No. 12 p.1345 ~ p.1355
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Hot-water Extract of Rubus Coreanus Miquel Suppresses VEGF-induced Angiogenesis
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Kim Eok-Cheon
Kim Hye-Jin
Kim Tack-Joong
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Abstract
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The interruption of angiogenesis using herbal extracts is now recognized as a useful approach for treating many solid tumors. To date, the best-validated antitumor approach is to target the vascular endothelial growth factor (VEGF)-induced angiogenic pathway. In the present study, we first identified the antiangiogenic activity of a hot-water extract of Rubus coreanus Miquel (RCMHE) in vitro and ex vivo. This extract suppressed VEGF-induced angiogenesis, the phosphorylation of extracellular regulated kinase (ERK), p38 and the activation of matrix metalloproteinases (MMPs). RCMHE also inhibited the VEGF-responsive phosphorylation of VEGFR2. These results clearly show that RCMHE may have potential therapeutic value for angiogenesis-associated human diseases through the suppression of angiogenesis and the interruption of the phosphorylation of VEGFR2.
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KEYWORD
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Angiogenesis, hot-water extract of Rubus coreanus Miquel, VEGFR2 phosphorylation
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